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pentobarbital will decrease the level or outcome of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Pitolisant exposure is decreased by 50% if coadministered with robust CYP3A4 inducers.pentobarbital will lessen the level or impact of abiraterone by impacting hepatic/intestinal enzyme